منابع مشابه
Spindle Microtubules: Getting Attached at Both Ends
A recent study describes a novel role for the centrosomal protein Cep57 in attaching spindle microtubules to both kinetochores and centrosomes, suggesting similar mechanisms may be used for generating these two distinct linkages in mitosis.
متن کاملSpindle asymmetry drives non-Mendelian chromosome segregation.
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their transmission through a process known as meiotic drive. In female meiosis, selfish elements drive by preferentially attaching to the egg side of the spindle. This implies some asymmetry between the two sides of the spindle, but the molecular mechan...
متن کاملDynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation
The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light chain 1 (DYNLL1) is required for this asymmetric cortical localization of dynein and has a speci...
متن کاملLET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
G-protein signaling plays important roles in asymmetric cell division. In C. elegans embryos, homologs of receptor-independent G protein activators, GPR-1 and GPR-2 (GPR-1/2), function together with Galpha (GOA-1 and GPA-16) to generate asymmetric spindle pole elongation during divisions in the P lineage. Although Galpha is uniformly localized at the cell cortex, the cortical localization of GP...
متن کاملA Discussion on Concept of Symmetry snd Asymmetry
This paper is concerned about the concept os asymmetry. The different types of asymmetry for univariate and multivariate distributions have introduces been considered as well as some of usual asymmetry criteria. A brief overview of method for adding the capability of modeling asymmetry to a symmetry distribution is also a secondary purpose of this paper.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2003
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0803-692